In my experience, there are indeed differences between artist grade and craft store acrylics. The main distinction lies in the pigment load, with artist grade acrylics having a higher concentration leading to richer, more vibrant colors. Additionally, artist grade acrylics offer a broader range of colors and greater longevity, although they tend to be more expensive. However, craft store acrylics are perfectly suitable for beginners or hobbyists, as they're more affordable and easier to work with. Ultimately, the choice between the two depends on your project, skill level, and budget.